Orthophytum itambense Versieux & Leme is described and illustrated as a new species, with an endemic distribution restricted to Pico do Itambé State Park, Minas Gerais, Brazil. This new lithophytic taxon is closely related to O. supthutii E. Gross & Barthlott due to the shape and texture of leaves, floral bracts with recurved apex, sessile inflorescence, and by the long tubular corolla. The new species differs from its closest relatives by having leaves white-lepidote abaxially and adaxially, with trichomes forming white transverse cross-bands adaxially, nearly free sepals, white corolla, and shorter petal appendages (only to 4 mm vs. to 7 mm in O. supthutii).